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​Lab news

Our lab very first pre-print on bioRxiv

11/1/2021

 
We are very excited to share our lab very first pre-print on bioRxiv. This work, led by our PhD student Hilary Yong, identified functional roles of CaMKIIα-mediated phosphorylation on the C-terminal tail of the GluN2A subunit (Ser-1459) in regulating the gating and activity-dependent trafficking of NMDA receptors. It is an extension of our recent collaborative work that was published in Cell Reports (Vieira et al., 2020). We thank all authors and our wonderful collaborators, Prof. Brett Collins (IMB, UQ), Dr. Angelo Keramidas (IMB, UQ), Prof. Joe Lynch (QBI, UQ) and Prof. Katherine Roche (NINDS, NIH, USA). 
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End of Year 2020 Awards

14/12/2020

 
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Even though 2020 has been a tough year, we have performed well with 7 published papers, two of which were led by PhD students, River and Hilary. To cap off the year, the lab was awarded the Judy Mitchell MND Research Innovator Grant by the MND Research Australia. This grant was jointly awarded to Victor, Jocelyn and our collaborator, Dr. Mihwa Lee (La Trobe University) to investigate molecular mechanisms underlying the cytoplasmic aggregation of the RNA binding protein, SFPQ, in ALS. Finally, we are very proud of Hilary, whose work on PICK1 in synaptic vesicle recycling (Yong et al., Cell Reports, 2020) was selected as the Runner Up of QBI Best Student Publication Prize 2020. We wish everyone a happy festive season and all the very best in 2021.  

PICK1 controls activity-dependent synaptic vesicle cargo retrieval

27/10/2020

 
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Our latest work has just been published in Cell Reports showing a new role for PICK1 (the only protein with a BAR and a PDZ domain) in regulating the activity-dependent clustering and retrieval of presynaptic vesicle cargo in mammalian central neurons. It is required for efficient synaptic vesicle endocytosis and sustained glutamate release. Outstanding work by Hilary and a wonderful collaboration with Prof. Mike Cousin (The University of Edinburgh, UK). 

A link between the dysregulation of m6A signalling and Alzheimer's disease

17/8/2020

 
We are excited to share our new work, "Altered expression of the m6A methyltransferase METTL3 in Alzheimer's disease", which has just been published in eNeuro. Here we report a decrease in the expression of METTL3 mRNA and soluble protein in the postmortem hippocampal tissues of Alzheimer's disease (AD) patients. We also identified a striking alteration in the METLL3 protein expression, including enhanced insolubility and immunoreactivity in the AD hippocampus. Our results suggest that perturbation of m6A signalling may present a novel cellular mechanisms underpinning dysregulation of gene expression associated with AD pathophysiology. Congratulations to River and Jocelyn who led this study and to our QBI collaborators, Drs. Judith Camats-Perna and Rodrigo Medeiros. 
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Congratulations to Sumasri, Hilary and Jocelyn

2/7/2020

 
We wish to congratulate the following lab members for their achievements:
  • Dr. Sumasri Guntupalli - for successfully passing her doctoral thesis and completing her PhD degree. Sumasri is the lab's second PhD graduate and we are very proud of her. 
  • Hilary Yong - for being awarded the prestigious Ian Lindenmayer PhD Top-Up Scholarship (up to 4 years of support). We also extend our gratitude to the Lindenmayer family for their generous gift which enabled this award. The top-up scholarship was established in 2019 and funded from a donation from Robina Lindenmayer in the name of her husband, Ian Lindenmayer.
  • Dr. Jocelyn Widagdo - for being awarded a UQ Amplify Fellowship (2020 - 2022) that continues to support her research in the epitranscriptomics mechanisms underlying neuronal plasticity, as well as providing her the opportunity to engage with students through undergraduate teaching at the School of Chemistry and Molecular Biology.  

PKC augments subunit-specific ubiquitination of AMPA receptors

12/2/2020

 
We are delighted that our study, primarily done by Jocelyn and Jun Wei, has just been published in Cellular and Molecular Neurobiology. Here, we demonstrated the cross-modulation between the ubiquitination and phosphorylation of the GluA2 subunit of AMPA receptors by protein kinase C (PKC). Interestingly, this effect is specific for GluA2 as phorbol ester does not potentiate bicuculline-induced ubiquitination of the GluA1 subunit. We envisage that the binding of glutamate on AMPARs in neurons with high level of PKC activity (such as following the activation of mGluRs) will result in subunit-specific regulation of AMPAR ubiquitination and intracellular sorting, which ultimately govern the subunit composition and number of AMPARs, including the Ca2+-permeable AMPARs at synapses. 
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Regulation of NMDA receptor functions by the GluN2 subunits

26/1/2020

 
The N-methyl-D-aspartate glutamate receptors (NMDARs) mediate calcium-dependent signaling that underpins multiple forms of synaptic plasticity. Different GluN2 (GluN2A-D) subunit confers NMDARs with distinct ion channel properties and intracellular trafficking pathways. In a review article which has just been published in Journal of Neurochemistry, we discuss the current knowledge of the molecular mechanisms that regulate the trafficking of GluN2-containing NMDARs, focusing on the roles of several key synaptic proteins that interact via their carboxyl termini. This review article is a joint effort with our collaborator Prof. Katherine Roche (NINDS, NIH). Congratulations to Marta (Roche Lab) and Hilary (Anggono Lab) on an excellent work. 
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New additions to the Anggono Lab in the new year 2020

6/1/2020

 
We are excited to welcome Dr. Anson Tan (postdoctoral fellow) and Mr. Sooraj Das (PhD student), who have just joined the Anggono Lab to investigate the mechanisms of glutamate receptor trafficking in neurons. Anson received his PhD from the University of Melbourne studying the mechanisms of APP trafficking under the supervision of Prof. Paul Gleeson, while Sooraj received his BS-MS double degree from the Indian Institute of Science Education and Research (IISER) Pune, India. We are also very fortunate to retain Ms Hilary Yong (former Research Assistant), who will pursue her PhD degree in the lab. Both Sooraj and Hilary received highly competitive Research Training Program Scholarships from the Australian Government. 

PTY Student from the University of Exeter

2/9/2019

 
We are delighted to welcome Mr. Liming Yang, a third year Bachelor of Medical Science student from the University of Exeter, UK. Liming will undertake a one-year research in the Anggono Lab as part of the Professional Training Year programme. 

The Anggono Lab Graduates

18/7/2019

 
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Congratulations to our recent graduates: Joanne Jang (PhD), Huimin Guo (MSc) and Wendy Kao (BSc - First Class Honours). Joanne has started her postdoctoral fellowship at the National Neuroscience Institute in Singapore. We wish you all the very best. 

The Lab has got its first PhD graduate

15/2/2019

 
A big congratulations to Joanne, who has been awarded her PhD degree and has officially became our lab's first PhD graduate. Well done!!!

New students joining the lab

23/7/2018

 
We are delighted to have 3 new students joining the lab in July 2018. They are River Huang (PhD student), Huimin Guo (MSc student) and Wendy Kao (Honours student). River was supported by a highly competitive UQ Research Training Scholarship. Congrats and warm welcome to our newest members in the lab.  

Synaptic mechanism of general anaesthetic

10/1/2018

 
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A major collaborative paper led by A/Prof. Bruno van Swinderen (QBI, UQ) has just been published in Cell Reports, describing the effect of a widely used general anaesthetic, propofol, in impairing the presynaptic release of neurotransmitters. Propofol restricts syntaxin 1a mobility on presynaptic membranes, a process that is dependent on another SNARE molecule, SNAP-25. Members of the Anggono Lab who were involved in this study include James Steeves (former Research Assistant) and Shu Liu (former Wen Zhou Scholar). [Press Release]

Regulation of FTO function by protein ubiquitination

10/12/2017

 
Tianyi, Hilary and Jocelyn have just published a research article in the Journal of Molecular Biology, reporting that the fat mass and obesity-associated (FTO) protein undergoes post-translational ubiquitination at Lys-216 of the N-terminal catalytic domain. By using the CRISPR/Cas-9 approach, they further showed that FTO K216R knock-in cells have a slower rate of FTO protein turnover. In addition, these cells display a defect in FTO translocation into the nucleus following amino acid starvation. Great effort by the team and congrats! 
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37th Annual Meeting of the Australasian Neuroscience Society

7/12/2017

 
Six members of the Anggono Lab attended the 37th annual meeting of the Australasian Neuroscience Society (ANS), which was held at the International Convention Centre in Sydney from 3 to 6 Dec 2017. Victor presented a talk at the "Synaptic Dysfunction in Neurodegenerative Diseases" symposium, while Jocelyn and Sumasri each gave a presentation in the "Synaptic Function and Plasticity" session. Meanwhile, Iris, Joanne, Tianyi and Sumasri also presented posters at the meeting. 

Joanne's image of a dendrite, "Rainbow after STORM" was named as the runner up of the ANS students' Images of Neuroscience photographic competition. Congratulations! 
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8th Brisbane Cell & Developmental Biology Meeting

21/11/2017

 
Joanne and Sumasri represented the Anggono Lab in the 8th Brisbane Cell & Developmental Biology Meeting, which was held on Nov 21, 2017 at the Translational Research Institute (TRI). Sumasri presented a poster while Joanne was selected to present a short talk. Joanne also won the Best Imaging Competition with her work, "The BrainSTORM". Congrats!
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Regulation of AMPA receptor trafficking by protein ubiquitination

26/10/2017

 
In this article, which has just been published in the Frontiers of Molecular Neuroscience, we review recent advances in the field and provide insights into the role of protein ubiquitination in regulating AMPA receptor trafficking and function in health and disease.
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The Anggono Lab at the inaugural Australian C. elegans Symposium

25/10/2017

 
The Anggono Lab was well represented at the inaugural Australian C. elegans symposium, which was held at the Queensland Brain Institute, Brisbane, 25-27 October 2017. Joanne, Sumasri and Iris each gave a talk in the Synapse Formation and Function session. 

New additions to the Anggono Lab

1/8/2017

 
​Welcome Varun and Wendy to the Anggono Lab. Varun comes from the Kadener Lab (The Hebrew University, Israel) and will stay in our lab for 3 months as an occupational trainee, while Wendy, a 3rd year undergraduate student at UQ, will receive training in basic molecular biology skills. 

Activation of GIRK channels by p75 neurotrophin receptors underlies Aβ-induced neuronal death

26/7/2017

 
Joanne and Victor publish a collaborative paper with the Coulson Lab (UQ) in Frontiers in Neuroscience, reporting the role of G-protein-coupled Inwardly Rectifying Potassium (GIRK/Kir3) channels and p75 neurotrophin receptors in mediating potassium efflux during Aβ-induced neuronal death. 
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Double celebration for Tianyi

22/7/2017

 
The lab celebrates the graduation of our first Master (research intensive) student, Tianyi, who passed with flying colours and received the Dean's Commendation for Academic Excellence. On the same day, Tianyi also learnt that he was awarded a highly competitive UQ International Graduate School Scholarship to pursue his PhD in the Anggono Lab. Well done Tianyi and congrats!!!
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J. Biol. Chem. Virtual Issue on Ion Channels

11/7/2017

 
We are pleased and honoured that our recent paper on the role of GluA1 ubiquitination in mediating amyloid-beta-induced removal of surface AMPA receptors (Guntupalli et al., J. Biol. Chem., 2017) was featured in the Journal of Biological Chemistry virtual issue on Ion Channels. 
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2017 Wenzhou Summer Student Program

11/7/2017

 
We are pleased to welcome Ms Jun Chen, a Wenzhou Summer Scholar who will undertake a short research project for the next 6 weeks in the Anggono Lab. This is the second time the Anggono Lab participates in the Wenzhou Summer Student Program, which selects only a handful of outstanding undergraduates through a competitive application and interview process. Welcome Jun! 

Welcome Xiaojun, our new PhD candidate

29/5/2017

 
Supported by a highly competitive International UQ Graduate School Scholarship, Xiaojun will investigate the molecular mechanisms of glutamate receptor trafficking in central neurons.

Our new paper in JBC - GluA1 ubiquitination in amyloid-β-induced synaptic depression

4/4/2017

 
​Sumasri, Joanne, Tianyi and Jocelyn publish an article in the Journal of Biological Chemistry, reporting a role for GluA1 ubiquitination in mediating amyloid-β-induced synaptic depression in neurons.
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