Transcriptional control of neuroblast migration in adult mouse ventricular-subventricular zone

A new collaborative paper in Cerebral Cortex led by the lab of A/Prof. Michael Piper (School of Biomedical Sciences, UQ) has revealed a role of the transcription factor NFIX (Nucleor Factor I X) in neuroblast migration within the adult mouse ventricular - subventricular zone. Conditional ablation of NFIX from neural stem or progenitor cells, or neuroblasts causes migration defects due to aberrant neuroblast branching, partly resulted from an increased expression of the guanylyl cyclase natriuretic peptide receptor 2 (Npr2). Congratulations to the team, especially Oressia and Lachlan from the Piper Lab!