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​Lab news

Modulation of L-type voltage-gated calcium channels by 1,25-dihyroxyvitamin D in developing medial prefrontal cortex

12/11/2019

 
Genetic variants in genes encoding L-type voltage-gated calcium channel (L-VGCC) subtypes are associated with increased risk for schizophrenia. Likewise, epidemiological study has implicated developmental vitamin D deficiency as a risk factor for schizophrenia. In the latest study published in Translational Psychiatry, we (led by Prof. John McGrath of QBI, UQ and Aarhus University, Denmark) showed that the active vitamin D metabolite exert a rapid, non-genomic modulation of L-VGCCs in a subset of neurons in developing medial prefrontal cortex in mice. Optimal modulation of L-VGCCs by 1,25(OH)2-vitamin D may therefore contribute to the healthy development of Vitamin D-responsive neurons within the maturing cortical circuits. 
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The possible links between Contactins and Alzheimer's disease

6/11/2019

 
We are pleased to co-publish a new review article with our collaborator Dr. Asami Oguro-Ando (University of Exeter, UK) in the journal Neuroscience. Led by Dr. Rosie Bamford, a Churchill Fellow who spent some times in the Anggono Lab this year, we propose possible links between contactins and their interactions with amyloid precursor proteins (APP) in the pathogenesis of Alzheimer's disease. Dysregulations of these cell surface recognition molecules may exert negative impacts on APP processing, synaptic plasticity and neuronal integrity. Read also the commentary on our article by Chatterjee and Teunissen.
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    Synaptic Neurobiology Lab

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