The N6-methyladenosine RNA landscape in the aged mouse hippocampus

Our new research describing the m6A-epitranscriptomic profiles from the hippocampi of young (3 month-old) vs aged (20 month-old) C57Bl/6 mice is now out in Aging Cell. We reveal more over 500 transcripts that are differentially methylated. There is also a significant concordance between m6A and transcript levels in both directions. Finally, we found that the myelin regulator gene Gpr17 was downregulated in the aged hippocampus concomitant with reduced m6A levels in its 3'UTR. Overall, the positive correlation between m6A and the transcript expression levels indicates a co-transcriptional regulation of m6A with gene expression changes that occur in the aged mouse hippocampus. Congratulations to River and Jocelyn who lead the project, as well as to our fantastic collaborators Drs. Renhua Song and Justin Wong (Centenary Institute, Sydney). 

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