In this article, which has just been published in the Frontiers of Molecular Neuroscience, we review recent advances in the field and provide insights into the role of protein ubiquitination in regulating AMPA receptor trafficking and function in health and disease.
The Anggono Lab was well represented at the inaugural Australian C. elegans symposium, which was held at the Queensland Brain Institute, Brisbane, 25-27 October 2017. Joanne, Sumasri and Iris each gave a talk in the Synapse Formation and Function session.
Victor presented a poster entitled "GluA1 ubiquitination mediates amyloid-β-induced loss of surface AMPA receptors" at the Australia Dementia Forum 2017, which was held at the Melbourne Convention & Exhibition Centre, 15 - 17 October 2017, and we were delighted to receive the Best Poster Award under the theme of Intervention. Victor also had the opportunity to present our research progress at the Forum, as part of the group presentation by the Clem Jones Centre for Ageing Dementia Research led by our Director, Prof. Jürgen Götz.
A major work from the Woodin Lab (University of Toronto) has just been published in eLife, in which Victor is a co-author. This is the first report describing the native KCC2 interactome in the brain. They found that KCC2 interacts with PACSIN1 (also known as syndapin1) to regulate synaptic inhibition in neurons.
Synaptic Neurobiology Lab