The m6A-epitranscriptomic signature in neurobiology

Jocelyn's new review article in the Journal of Neurochemistry is now online. ​N6-methyladenosine (m6A), the most prevalent internal modification on eukaryotic RNA, modulates transcript stability, splicing and translation efficiency. Activity-dependent m6A in the central nervous system provides a versatile and important mechanism to control RNA structure and function. This review article provides the current knowledge of m6A function and mechanism in neurobiology, highlighting the critical roles of m6A-epitranscriptomic regulation in multiple aspects of the mammalian nervous system, from neural development to plasticity in learning and memory.

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