Syntaxin1A neomorphic mutations promote rapid recovery from isoflurane anesthesia in fruit flies
A collaborative study from the van Swinderen laboratory (QBI, UQ) published in Anesthesiology, has shown that transiently expressing a truncated syntaxin1A (Δ227) in adult Drosophila flies facilitates recovery from isoflurane anesthesia. Interestingly, our biochemical study revealed that the truncated syntaxin1A is absence from the presynaptic SNARE complex, suggesting that the resistance-promoting effect occurs prior to SNARE formation.
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Synaptic Neurobiology Lab