Tianyi Zhu et al. (Volume 430/3) show that active ubiquitination of FTO mediates its proteasomal degradation, as well as its translocation into the nucleus during nutrient deprivation. The cover depicts an artistic rendition of FTO translocation into nuclei, which are stained by DAPI. The small puncta represent ubiquitinated FTO as revealed by the proximity ligation assay using anti-FTO and anti-ubiquitin antibodies.
Cell artwork by Jocelyn Widagdo. Background visual design by Miriam Bucheli (Elsevier/Scientific Editor and Visual Designer).
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Synaptic Neurobiology Lab