Jocelyn Widagdo, Ph.D.

Education
BSc (Hons I) in Bioinformatics
University of Sydney, Australia (2007)

PhD 
University of New South Wales, Australia (2011)

Positions
Postdoctoral Fellow (2011 - 2012)
​Johns Hopkins University School of Medicine, Baltimore, USA

Postdoctoral Fellow (2012 - 2016)
Queensland Brain Institute, The University of Queensland, Brisbane, Australia

Research Fellow (2017 - present)
Queensland Brain Institute, The University of Queensland, Brisbane, Australia

Awards
2007 - University of Sydney Postgraduate Award

2010 - OzBio Student Bursary Award, Australian Society for Biochemistry and Molecular Biology (ASBMB)

2012 - Paper of the Month Award (Widagdo et al., PLoS One, 2012), School of Medical Sciences, University of New South Wales

2013 - The Ian Potter Foundation Travel Award

2013 - The Lorne Genome Travel Grant

2017 - Australian Research Council (ARC) Discovery Early Career Researcher Award

2017 - Young Investigator Travel Award, International Society for Neurochemistry
​
2018 - Young Investigator Travel Award, Asian-Pacific Society for Neurochemistry

Research Support
ARC DECRA Fellowship (DE170100112) “Epitranscriptomic regulation of learning and memory”. CIA, 2017 - 2019

UQ Early Career Researcher Grant "The epitranscriptomic landscape of ageing and dementia". CIA. 2018.

Invited Seminars
  • Department of Anatomy/Physiology/Pharmacology, University of New South Wales, Sydney, October 2011.
  • Brisbane Cell and Developmental Biology Annual Meeting, Australia and New Zealand Society for Cell and Developmental Biology (ANZSCDB), Brisbane, October 2015.
  • ​Queensland Brain Institute, The University of Queensland, Brisbane, October 2016.
  • Mechanisms and Mysteries in Epigenetics Conference, Sydney, April 2016.
  • 39th Meeting of Japan Neuroscience Society, Yokohama, Japan, 20-22 July 2016. 
  • Young Investigator Colloquium, 26th Meeting of the International Society for Neurochemistry, Paris, France, 20-24 August 2017. 
  • 37th Australasian Neuroscience Society Annual Meeting, Sydney, 3-6 December 2017.

Professional Activities
Ad-hoc Reviewer:
  • Journal of Neurochemistry
  • Neural Plasticity
  • Scientific Reports

Grant Reviewer:
  • NHMRC
  • Australian Research Council (ARC)

Publications
  1. Palmer SJ, Santucci N, Widagdo J, Bontempo SJ, Taylor KM, Tay ES, Hook J, Lemckert F, Gunning PW, Hardeman EC (2010) Negative autoregulation of GTF2IRD1 in Williams-Beuren syndrome via a novel DNA binding mechanism. Journal of Biological Chemistry 285, 4715-4724.
  2. Palmer SJ, Taylor KM, Santucci N, Widagdo J, Chan YK, Yeo JL, Adams M, Gunning PW, Hardeman EC (2012) GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members. Journal of Cell Science 125, 5040-5050.
  3. Widagdo J, Taylor KM, Gunning PW, Hardeman EC, Palmer SJ (2012) SUMOylation of GTF2IRD1 regulates protein partner interactions and ubiquitin-mediated degradation. PLoS One 7, e49283.
  4. Anggono V, Koç-Schmitz Y, Widagdo J, Kormann J, Quan A, Chen CM, Robinson PJ, Choi SY, Linden DJ, Plomann M, Huganir RL (2013) PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression. Proceedings of the National Academy of Sciences of the USA 110, 13976-13981.
  5. Li X, Wei W, Zhao QY, Widagdo J, Baker-Andersen D, Flavell CR, D’Alessio A, Zhang Y, Bredy TW (2014) Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioural adaptation. Proceedings of the National Academy of Sciences of the USA 111, 7120-7125. Recommended by the Faculty of 1000.
  6. Widagdo J, Chai YJ, Ridder MC, Chau YQ, Johnson RC, Sah P, Huganir RL, Anggono V (2015) Activity-dependent ubiquitination of GluA1 and GluA2 regulates AMPA receptor intracellular trafficking and degradation. Cell Reports 10, 783-795. Recommended by the Faculty of 1000.
  7. Widagdo J, Anggono V (2015) Ubiquitination signals the demise of AMPA receptors. Oncotarget 6, 15718-15719. (Invited Editorial)
  8. Spadaro P, Flavell CR, Widagdo J, Ratnu VS, Troup M, Ragan C, Mattick JS, Bredy TW (2015) Long noncoding RNA-directed epigenetic regulation of gene expression is associated with anxiety-like behavior in mice. Biological Psychiatry 78, 848-859.
  9. Carmona-Mora P, Widagdo J, Tomasetig F, Canales CP, Cha Y, Lee W, Alshawaf A, Dottori M, Hardeman EC, Palmer SJ (2015) The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation. Human Genetics 134, 1099-1115.10.      
  10. Guntupalli S*, Widagdo J*, Anggono V (2016) Amyloid-β-induced dysregulation of AMPA receptor trafficking. Neural Plasticity 2016, 3204519. *co-first author.
  11. Widagdo J*#, Zhao Q*, Kempen MJ, Tan MC, Ratnu VS, Wei W, Leighton L, Spadaro PA, Edson J, Anggono V, Bredy TW# (2016) Experience-dependent accumulation of N6-methyladenosine in the prefrontal cortex is associated with memory processes in mice. Journal of Neuroscience 36, 6771-6777. *co-first author, #co-corresponding author.
  12. Widagdo J*, Fang H*, Jang SE, Anggono V (2016) PACSIN1 regulates the dynamic of AMPA receptor trafficking. Scientific Reports 6, 31070. *co-first author.
  13. Clairfeuille T, Mas C, Chan ASM, Yang Z, Tello-Lafoz M, Chandra M, Widagdo J, Kerr MC, Paul B, Mérida I, Teasdale RD, Pavloz NJ, Anggono V, Collins BM (2016) A molecular cole for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex. Nature Structural & Molecular Biology 23, 921-932.
  14. Guntupalli S, Jang SE, Zhu T, Huganir RL, Widagdo J, Anggono V (2017) GluA1 subunit ubiquitination mediates amyloid-β-induced loss of surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Journal of Biological Chemistry 292, 8186-8194.
  15. Tan MC*, Widagdo J*#, Chau YQ, Zhu T, Wong JJ, Cheung A, Anggono V# (2017) The activity-induced long non-coding RNA Meg3 modulates AMPA receptor surface expression in primary cortical neurons. Frontiers in Cellular Neuroscience 11, 124. *co-first author, #co-corresponding author.
  16. Lin Q, Ponnusamy R, Widagdo J, Choi JA, Ge W, Buckley T, Probst C, Luo M, Bredy TW, Fanselow MS, Ye K, Sun YE (2017) MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life. Proceedings of the National Academy of Sciences of the USA 114, 9188-9193.
  17. Widagdo J, Guntupalli S, Jang SE, Anggono V (2017) Regulation of AMPA receptor trafficking by protein ubiquitination. Frontiers in Molecular Neuroscience 10, 347.
  18. Zhu T, Yong XLH, Xia D, Widagdo J*, Anggono V* (2018) Ubiquitination mediates proteasomal degradation and nuclear translocation of the fat mass and obesity-associated (FTO) protein. Journal of Molecular Biology 430, 363-371. *co-senior author.

Student Supervision
Current
  • Sumasri Guntupalli (PhD student, 2015 - present)
  • Tianyi Zhu (PhD student, 2017 - present)
  • Yung Ching Kao (Summer Scholar, 2017 - present)

Completed
  • Marie-Jeanne Kempen (Masters student, 2014)
  • Laura Leighton (Honours student, Class I, 2014)
  • Paola Spadaro (PhD student, 2015)
  • Tianyi Zhu (MSc student, 2016 - 2017)
  • Phaedra K. Stevens (Honours student, Class I, 2017)